Chromosome 9p21 Amplification in HNSCC Is Associated With Increased Mortality Following Adjuvant Radiation Therapy
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چکیده
منابع مشابه
ANRIL expression is associated with atherosclerosis risk at chromosome 9p21.
OBJECTIVE We tested the hypothesis that expression of transcripts adjacent to the chromosome 9p21 (Chr9p21) locus of coronary artery disease was affected by the genotype at this locus and associated with atherosclerosis risk. METHODS AND RESULTS We replicated the locus for coronary artery disease (P=0.007; OR=1.28) and other manifestations of atherosclerosis such as carotid plaque (P=0.003; O...
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Man has been exposed to different levels of natural background radiation since the creation of human life. There are inhabited areas around the world with extraordinary levels of natural background radiation. The level of natural radiation in these areas is up to two orders of magnitude higher than other places. Areas such as Yangjiang, China; Guarapari, Brazil; and Kerala, India are among the ...
متن کاملChromosome 9p21 polymorphism is associated with myocardial infarction but not with clinical outcome in Han Chinese.
BACKGROUND rs1333049 polymorphism on chromosome 9p21 has been shown to affect susceptibility to coronary artery disease (CAD) in Caucasians. This study examined the association of rs1333049 with myocardial infarction (MI), angiographic severity of CAD and clinical outcome after a first acute MI in Han Chinese. METHODS rs1333049 polymorphism was genotyped in 520 patients with a first acute MI ...
متن کاملPrehospital hypothermia is associated with increased mortality.
Introduction Trauma is leading cause of death among people under the age of 40.[1] Accidental hypothermia, acidosis, and coagulopathy represent the lethal triad in severely injured patients. [2] There is good evidence that unintended hypothermia worsens outcomes after major trauma.[3] We aimed to audit the frequency of hypothermia among seriously injured patients presenting to a UK major trauma...
متن کاملAdjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skin.
PURPOSE Merkel cell carcinoma (MCC) is a rare cutaneous malignancy. Because of the absence of randomized studies, the real benefit of adjuvant radiation therapy in MCC is unclear. The aim of this study was to better define the role of adjuvant radiation therapy in the management of MCC. METHODS The Surveillance, Epidemiology, and End Results (SEER) survey from the National Cancer Institute wa...
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ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2015
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2015.07.341